Clinical evidence

Not a promise. Peer-reviewed proof.

Every claim ORamaVR makes about clinical outcomes is backed by published, peer-reviewed research, conducted independently at hospitals, medical schools, and specialist centres across three continents.

Clinical trials

Independent, peer-reviewed clinical evidence.

Randomised controlled trials, feasibility studies, and clinical interventions conducted by independent research institutions using the ORamaVR platform.

ERMIS (Enhanced Robotic Medical Immersive Simulator) Validation Pilot Study

Pilot validation of ermisVR, ORamaVR's robotic surgery training simulator. Karava A, Sgouridis A, Anagnostopoulos D, et al.
In press Journal of Robotic Surgery (2026) Read preprint →

The Impact of Immersive Virtual Reality Training in Thyroid Surgery: A Prospective Randomized Controlled Trial

Blinded RCT with general surgery residents comparing immersive VR training to traditional learning for thyroidectomy.
23% Faster task completion
OSATS ↑Performance, instruments, flow
27.25 / 35.25 Minutes, VR vs traditional
Updates in Surgery, Springer (2025) Read paper →

The Effect of Physical Exercise with Cognitive Training on Inflammation and Alzheimer’s Disease Biomarkers of Mild Cognitive Impairment Patients

Clinical trial of VR-based combined physical and cognitive training in MCI patients.
↓Cytokines (IL-1β, IL-6, TNF-α)
↑Aβ42/40 ratio, p-tau
↑Cognitive gains
Neuroscience Applied, Elsevier (2024) View PDF →

Effectiveness of VR Compared to Video Training on Acetabular Cup and Femoral Stem Implantation Accuracy in Total Hip Arthroplasty

RCT comparing VR training to video instruction for medical students performing THA.
p<0.001 Cup placement accuracy
p=0.008 Stem anteversion
p=0.016 Fewer retroversion errors
International Orthopaedics, Springer (2024) View PDF →

Training for Better Transfer in an Online Competency-Based Higher Education Program: Technology’s Role in Preparing the Next Generation Workforce

Evaluates VR simulation as a competency-based assessment tool at Western Governors University.
VR-specific Limiters identified
Design Guidance produced
Advances in Educational Technologies (2023) View PDF →

VRADA Training System as a Non-Pharmacological Dual Intervention to Alleviate Symptoms of the Pathophysiology of Mild Cognitive Impairment

Evaluates the VRADA system for combined physical and cognitive training in MCI patients.
78–83 SUS usability score
p<0.001 VR preference
Minimal Adverse effects
Brain Disorders, Elsevier (2023) View PDF →

Development and Usability Testing of a Fully Immersive VR Simulation for REBOA Training

Usability evaluation of a VR simulation for resuscitative endovascular balloon occlusion of the aorta, a rare, high-stakes trauma procedure.
77.5 SUS usability score
26/30 USEQ score
p<0.001 Trainee confidence ↑
International Journal of Emergency Medicine (2023) View PDF →

Virtual Reality Medical Training for COVID-19 Swab Testing and Proper Handling of PPE: Development and Usability

Architecture and validation of a medical XR simulation for COVID-19 swab testing and PPE training, based on a world-standard hygiene protocol.
Year 3–6 Medical students validated
≥ traditional Reported skill transfer
Frontiers in Virtual Reality (2022) View PDF →

A Digital Health Intervention for Stress and Anxiety Relief in Perioperative Care: Protocol for a Feasibility Randomized Controlled Trial

Published RCT protocol for a digital health VR intervention targeting perioperative stress and anxiety, evaluating the Adhera CARINAE wearable/mobile/VR programme.
5 Hospitals
60 Patients enrolled
Protocol Outcomes on completion
JMIR Research Protocols (2022) View PDF →

A Virtual Reality App for Physical and Cognitive Training of Older People With Mild Cognitive Impairment: Mixed Methods Feasibility Study

Mixed-methods feasibility study of a VR app combining physical and cognitive training for older adults with MCI.
82.7 / 78.0 SUS (students / older adults)
p<0.001 VR preference, both groups
Minimal Side effects
JMIR Serious Games (2021) View PDF →

Effectiveness and Utility of VR Simulation as an Educational Tool for Safe Performance of COVID-19 Diagnostics: Prospective, Randomized Pilot Trial

Prospective randomised pilot trial of VR simulation for COVID-19 swab and PPE training.
14 vs 12 Swab score, VR vs video (p=0.03)
27 vs 22 USEQ satisfaction (p=0.011)
1 month Retention sustained
JMIR Serious Games (2021) View PDF →

Virtual Reality Simulation Facilitates Resident Training in Total Hip Arthroplasty: A Randomized Controlled Trial

Blinded RCT of VR simulation for PGY-1 orthopaedic residents performing cadaveric total hip arthroplasty.
Blinded RCT, faculty assessment
VR > Technique-guide control
Multi-component Surgical technique gains
The Journal of Arthroplasty (2019) View PDF →

Case studies

Deployed at leading institutions worldwide.

From university hospitals to medical schools to specialist training centres, ORamaVR is in active use at institutions across three continents.

USA

University of Michigan, Medicine
Cardiac arrest resuscitation training
View case study →

Switzerland

Inselspital, Universitätsspital Bern
COVID-19 XR simulation programme
View case study →

Switzerland

Geneva University Hospitals, Centre for Virtual Medicine
Creator for OSCE development
View case study →

USA

NYU Langone Health
First-ever collaborative VR surgical training
View case study →

Germany

University Hospital Cologne
Abdominal anatomy and surgery XR collection
View case study →

USA

Western Governors University
Competency-based assessment simulations
View case study →

SE Europe

Sofmedica Group
Regional MedTech deployment
View case study →

Published research

Latest from the research team. Peer-reviewed proof.

The most recent publications from the ORamaVR team -- spanning robotic simulation, team-based VR training, computational medical XR, and platform research.

ERMIS: Enhanced Robotic Medical Immersive Simulator, Validation Pilot Study

Validation pilot study of a fully immersive VR simulator for robotic surgical training. Evaluates skill transfer, usability, and clinical validity of the ERMIS platform for robotic procedure education.
Read paper →

Non-linear, Team-based VR Training for Cardiac Arrest Care with Enhanced CRM Toolkit (iREACT)

Presents iREACT, a non-linear team-based VR training system for cardiac arrest resuscitation incorporating crew resource management (CRM) tools for emergency teams.
Read paper →

Geometric Algebra Meets Large Language Models: Instruction-Based Transformations of Separate Meshes in 3D, Interactive and Controllable Scenes

Demonstrates how geometric algebra and large language models can be combined to enable instruction-based 3D transformations in interactive medical simulation scenes.
Read paper →

Computational Medical Extended Reality (CMXR): Pioneering the Future of Healthcare Through Computational Medicine and Extended Reality

A course paper introducing the CMXR discipline, the intersection of computational medicine, XR technology, and AI for next-generation healthcare training and clinical applications.
Read paper →

Research Article, AIP Publishing (2024)

Technical research article published through AIP Publishing, advancing the scientific foundations of the ORamaVR platform and medical XR simulation methodology.
Download PDF →

Edge-driven Docker Registry: Facilitating XR Application Deployment

Presents an edge-computing approach to XR application deployment using a Docker registry architecture, enabling scalable and low-latency delivery of medical XR simulations.
Read paper →

VR Isle Academy: A VR Digital Twin Approach for Robotic Surgical Skill Development

Introduces a digital twin VR environment for robotic surgical training, enabling realistic practice of robotic-assisted procedures with accurate instrument simulation and performance feedback.
Read paper →

Effectiveness of VR Compared to Video Training on Acetabular Cup and Femoral Stem Implantation Accuracy in Total Hip Arthroplasty

Randomised controlled trial comparing VR training effectiveness against video instruction for medical students performing total hip arthroplasty. Assessed implantation accuracy and time to competency.
Read paper →

In their own words

What clinicians and educators are saying.

“We have worked with ORamaVR and our residents absolutely love training with the platform. This has really been good for our training, I am really trying to interest all my colleagues and training centers that this is necessary for them to make their residents better.”
Prof. Lawrence Dorr Orthopaedics, University of Southern California, Keck School of Medicine

“This was magnificent, it was really like live surgery. It is very easy to use, I would definitely promote it.”
Prof. Per Kjaersgaard-Andersen and Colleagues South Danish University, Denmark

“VR is the future of medical education and we are pushing further the limits with ORamaVR and Creator.”
Prof. Thomas Sauter Emergency Telemedicine, University of Bern, Switzerland

“Quite a fascinating teaching tool. It allows us to take residents through the case step by step without a cadaver or a book, a medium that they understand and can appreciate.”
Prof. Paul K. Gilbert Orthopaedics, University of Southern California, Keck School of Medicine

“Very nice experience and it will be very fruitful for young surgeons. It’s a great tool and helpful for the training.”
Lazaros A. Poultsides, MD, MSc, PhD NYU Langone Medical Associate

“Creator has streamlined our pipeline incredibly. The development and feedback loop has been so tight that in about one month we had a full-blown teaching tool.”
Sinan Vural CTO, Non Nocere, Germany

“Thanks to its high-quality toolset and capabilities, the Creator has allowed us to create and author simulations in a very time and resource efficient manner.”
Josh Tan Diagnostic Radiology, Atrium Health Wake Forest Baptist Medical Center, USA

“Creator allowed us to create VR content with minimal effort.”
Dr. Stefan Tuchschmid CO-CEO & Founder, VirtaMed AG

“Train anywhere, any time. Minimal equipment required for simulating the whole robotic experience.”
Sofmedica Pioneering Excellence in Medical Education and Innovation

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